
I hear you owe that boy a SIGNIFICANT debt.
Game of Thrones Season 3, Episode 3

How SIGNIFICANT?
Breaking Bad Season 2, Episode 10

If I had another SIGNIFICANT aspect
of my life...
The Big Bang Theory Season 2, Episode 3

...I'm going to go do work
that promises SIGNIFICANT results...
The Big Bang Theory Season 2, Episode 2

But there's been
a SIGNIFICANT reduction
in the tumors.
Breaking Bad Season 2, Episode 10